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Pages 323-327 (March 2009)

Effect of Statin Treatment on Mortality in a Large Cohort of Heart Failure Patients

Efecto del tratamiento con estatinas en la mortalidad de una gran cohorte de pacientes con insuficiencia cardiaca

Alejandro J JordánaManuel P Anguitab

https://doi.org/10.1016/S1885-5857(09)71565-8

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We studied 3162 heart failure patients included in the Spanish BADAPIC registry in order to determine whether statin treatment influences prognosis. Patients were followed up for 35±22 months (median, 32 months). Patients on statins were more often male and had higher prevalences of risk factors, ischemic heart disease and systolic dysfunction (P<.001) than those not on statins. After adjustment for age, risk factors, ischemic heart disease, renal failure, ejection fraction, anemia, heart rate and drug treatment, statin treatment was found to be a favorable independent predictor of survival: the hazard ratio for mortality was 0.73 (95% confidence interval, 0.45¿0.88; P<.001). During follow-up, the 3-year survival rate was higher in patients treated with statins (75% vs. 68%; P<.001). In patients with heart failure, statin treatment appears to be independently associated with better survival.

Keywords

Heart failure

Statins

Prognosis

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