In the article by Rodríguez-Serrano et al., “Familial Left Ventricular Noncompaction Associated With a Novel Mutation in the Alphacardiac Actin Gene”, published in Rev Esp Cardiol. 2014;67:857-9, the following errors were found:
Figure. In the last line of the family pedigree, where it says: “V: 1”, it should say: “IV:1”. The correct figure is:
Table. Row 7 has been duplicated by mistake. The characteristics of rows 4 and 6 (pedigree positions III:4 and III:6) have been switched. The correct table is:
Results From the Clinical Family Evaluation
| Pedigree position | Sex/Age, y | Clinical history | ECG | Echocardiography | CMRI | Holter | Exercise testing | Genetics: heterozygous ACTC1I289T mutation |
|---|---|---|---|---|---|---|---|---|
| II:3 | F/59 | Asymptomatic | Normal | Normal | — | — | — | Non carrier |
| II:4 | M/66 | Dyspnea, NYHAclass I-II/IV | SR, first degree AV block, QS in the inferior leads | One year before this study, in another center: echocardiography within normal limitsAt the beginning of this study: LVNC, normal LV size; LVEF, 36%; moderately impaired RVEFAt follow-up: upper limit LV diameters with hypertrabeculation; LVEF, 25%; normal RVEF | LVNC; LVEF, 48%; intramyocardial LGE at the inferior wall and posterior septum | SR, unremarkable isolated ventricular ectopies, unremarkable atrial ectopies in isolation, couplets and salvoes | Normal | Carrier |
| III:2 | F/33 | Asymptomatic | Normal | Normal | — | — | — | Non carrier |
| III:4 | M/31 | Dysnea, NYHA class II/IV | SR, nonspecific ventricular activation delay | LVNC; spheric-shaped dilated LV (65/52 mm); LVEF, 25%; restrictive filling pattern; severe mitral regurgitation; normal-sized RV with preserved RVEF | LVNC; dilated LV; LVEF, 27%; prolapse of posterior mitral left with severe mitral regurgitation. | SR; scarce atrial ectopies in couplets and salvoes; ventricular ectopies in isolation (1908); couplets (43), and one salvoe (5 beats) | Ventricular ectopies and 1 nonsustained ventricular tachycardia (3 beats) at peak exercise | Carrier |
| III:5 | M/37 | Asymptomatic | Normal | Normal | — | — | — | Non carrier |
| III:6 | F/32 | Previous clinical history: OS-ASD repaired at 10 years of age; one miscarriage (hydrops)At follow-up: Dyspnea class I-II/IV NYHA | Normal | Three years before this study, in another center: echocardiography within normal limitsAt the beginning of this study: normal LV size; LVEF, 53%; apical and septal hypertrabeculation, restrictive filling pattern normal sized RV with mildly impaired RVEFAt 1-year follow-up: upper limit LV diameters (51/43 mm); LVEF, 36%; restrictive filling pattern; apical hypertrabeculation not fullfilling criteria for LVNC; moderate tricuspid regurgitation without pulmonary hypertension. upper limit RV diameters with mildly impaired RVEFAt 2-year follow-up: improvement of LVEF and RVEF | Three years before this study, in another center: hypertrabeculation in lateral and inferolateral regions; normal sized LV; LVEF, 51%At the beginning of this study: LVNC more prominent at the anterolateral and inferolateral wall; dilated LV; LVEF, 55%; RVEF, 46%; subepicardial LGE at the inferior and lateral walls; akinetic biventricular apical segments | SR, isolated rare atrial and ventricular ectopies | Normal | Carrier |
| IV:1 | F/3 | Heart transplantation at 9 months of age because of refractory heart failure; no further clinical events | SR at 150 bpm; left atrial and LV hypertrophy and inespecific alteration in the ventricular repolarization | Before heart transplantation:dilated LV (36/27 mm) and LVEF, 46%; restrictive filling pattern; severe-moderate mitral and tricuspid regurgitation; moderate pulmonary hypertension; OS-ASD, 5 mmAt heart transplantation:LV hypertrabeculation | — | — | — | Carrier |
ACTC1, alpha-cardiac actin gene; AVB: atrioventricular block; CMRI, cardiac magnetic resonance imaging; ECG, electrocardiogram; F, female; LGE, late gadolinium enhancement; LV, left ventricle; LVEF, left ventricular ejection fraction; LVNC, left ventricular noncompaction; M, male; MI, myocardial infarction; NE, not evaluated; NYHA, New York Heart Association; OS-ASD, ostium secundum atrioseptal defect; RV, right ventricle; RVEF, right ventricular ejection fraction; SR: sinus rhythm.
These corrections were made in the electronic version of the article on 5 November 2014.